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Profile for Scott Cooper

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Scott Cooper

Office hoursE-mail me to set up a meeting.
Specialty area(s)Biochemistry and molecular biology of blood clotting.
Brief biographyI began teaching at UW-L in 1995. I am currently a full professor in biology with a 50% appointment as the director of Undergraduate Research and Creativity.
Current courses at UW-LRadiation Biology BIO 333
Molecular Biology BIO 435
Molecular Biology Lab BIO 436
Bioinformatics BIO 440
Molecular Mechanisms of Drugs and Disease Action BIO 443
Triathlon ESS 100
Teaching historyMolecular Biology lecture consists of four sections. In the first we look at the central dogma and regulation of gene expression. Next we focus on basic biotechnology techniques by examining the cloning and expression of human tissue plasminogen activator. In the next section the course we examine cellular processes including cancer, developmental biology and the production of transgenic and cloned animals. Finally we explore the role of proteomics and genomics in elucidating the function of BRCA1.

In Molecular Biology Lab students work on two projects that are part of the research programs of other faculty in biochemistry or cell and molecular biology. This allows the students to participate in a real research experiment. This also exposes them to several aspects of biotechnology research; yeast-two hybrid screening, site directed mutagenesis, cloning, and computer modeling. The students write their results in a peer-reviewed journal format.
Bioinformatics is a team taught course that focuses on the many applications of bioinformatics and the theoretical algorithms underlying these computer programs. There are four sections to the course; Databases, Phylogenetics, Genomics and Proteomics.

Molecular Basis of Disease and Drug Action examines the biological basis of many non-infectious and non-cancerous diseases and the drugs used to treat them. For each disease the students are given three perspectives; pathology, pharmacology and clinical. This course is team taught by Scott Cooper (pathology), Aaron Monte (pharmacology) and several M.D.s from local hospitals (clinical). There are five units in the course; Pathology and Pharmacology, Inflammation, Cardiovascular, Neurological, and Genetics. Students also give oral presentations on assigned diseases.

Radiation Biology is a course primarily for nuclear medical technology (NMT) and radiation therapy (RT) majors. It focuses on the effects of radiation on biological systems. The lab involves both exploring the properties of radiation, and the effects of radiation on biomolecules and cells.
Professional historyMy research focuses on the effects of hibernation on blood clotting. Ground squirrels that hibernate have increased blood clotting times to prevent clots from forming as their hearts slow and blood pressure drops. We are trying to understand how the squirrels regulate primary and secondary hemostasis to accomplish this. I typically have 8-10 teams of 3-4 students working on different aspects of this project.
Research and publishing1. Cooper ST, Richters KE, Melin TE, Liu ZJ, Hordyk PJ, Benrud RR, Geiser LR, Cash SE, Simon Shelley C, Howard DR, Ereth MH, Sola-Visner MC. The hibernating 13-lined ground squirrel as a model organism for potential cold storage of platelets. Am J Physiol Regul Integr Comp Physiol, 302(10), pp 1202-8, 2012.
2. Patrick R. Gonzales, Timothy D. Walston, Laureano O. Camacho, Dana M. Kielar, Frank C. Church, Alireza R. Rezaie, Scott Cooper. Mutation of the H-helix in Antithrombin Decreases Heparin Stimulation of Protease Inhibition. BBA Proteins and Proteomics, 1774 (11), pp 1431-1437, 2007.
3. Réhault, S.M., Zechmeister-Machhart, M.,, Binz, N.M., Fortenberry, Y.M., Cooper, S.T., Geiger, M., and F.C. Church Characterization of recombinant human protein C inhibitor expressed in Escherichia coli. Biochimica Biophysica Acta. 1748: 57-65, 2005
4. Likui Yang, Chandrashekhara Manithody, Timothy D. Walston, Scott T. Cooper, and Alireza R. Rezaie. Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding-site for the serpin and allosterically modulating the activity of thrombin. J. Biol. Chem. 278; p. 37465-37470, 2003.
5. Cooper, S.T., Rezaie, A.R., Church, F.C., and Esmon, C.T. Inhibition of a Thrombin Anion-Binding Exosite-2 Mutant by the Glycosaminoglycan-dependent Serpins Protein C Inhibitor and Heparin Cofactor II. Thrombosis Reseach 16: 67-73, 2002.
6. Cooper, S.T., Neese, L.L., Dicuccio, M., Liles, D.K., Hoffman, M. and Church, F.C. Heparin-binding Serpins are not Released Following Intravenous Heparin Injection. Clinical and Applied Thrombosis/Hemostasis 2: 185-191, 1996.
7. Cooper, S.T., Whinna, H.C., Jackson, T.P. and Church, F.C. Intermolecular Interactions Between Protein C Inhibitor and Coagulation Proteases. Biochemistry 34, 12991-12997,1995.
8. Rezaie, A.R., Cooper, S.T., Church, F.C., and Esmon, C.T. Protein C Inhibitor is a Potent Inhibitor of the Thrombin-thrombomodulin Complex. J. Biol. Chem 270: 25336-9, 1995.
EducationB.S. Biochemistry - Michigan State University, 1986

Ph.D. Biochemistry - University of Wisconsin-Madison, 1992

Post-Doc Pathology - University of North Carolina at Chapel Hill, 1993-1995
Important linksUndergraduate Research and Creativity.